Paired ends are preferred since they can identify both ends of the DNA fragments, which is where the transposase enzyme cuts. Paired end reads tend to offer higher unique alignment rates and allow you to reliably identify nucleosomal patterns (mono-, di-, tri-nucleosomes) useful for nucleosomal footprint analyses.
Do you need paired end data for ATAC seq? Print
Modified on: Thu, 3 Dec, 2020 at 10:40 PM
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